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What Is Normal Estrogen Level After Menopause

Blood Levels Of Estradiol

What is a normal range for menopause? – Women’s Healthy Hormones

In most laboratories, serum estradiol levels range from 20 to 80 pg/mL during the early to midfollicular phase of the menstrual cycle and peak at 200 to 500 pg/mL during the preovulatory LH surge. During the midluteal phase, serum estradiol levels range from 60 to 200 pg/mL.32

Before puberty, serum estradiol levels are less than 20 pg/mL, indistinguishable from cases of hypogonadism. After menopause, estradiol levels fall to prepubertal levels the mean serum estradiol level is typically 10 to 20 pg/mL, and levels are lower than 10 pg/mL in women who have undergone oophorectomy.

In men, serum estradiol levels should be less than 40 pg/mL, but may be increased in several testicular and nontesticular diseases. Serum estradiol levels are relatively constant and, unlike testosterone, are unchanged with age.33 In men, it is important to measure serum estradiol with assays that are able to distinguish between low values.

Male serum estrone levels should be less than 60 pg/mL. The measurement of serum estradiol and estrone may be useful in the clinical evaluation of hypogonadism and gynecomastia. However, obesity is the most common cause of mildly increased levels of circulating estrogens in men.33

JORGE R. PASQUALINI, … CHARLOTTE SUMIDA, in, 1991

What Causes Postmenopausal Bleeding

Vaginal bleeding during postmenopause isn’t a normal side effect of decreasing hormone levels. In some cases, the dryness in your vagina could cause some light bleeding or spotting after sex. In other cases, it could indicate a condition like endometrial hyperplasia or uterine fibroids, infections like endometritis, or cancer. Contact your healthcare provider if you experience any vaginal bleeding so you can be evaluated.

How Do I Stay Healthy After Menopause

It is important to maintain a healthy lifestyle, especially as you age and your risk for certain medical conditions increases. Some ways for people in postmenopause to stay healthy include:

  • Exercising regularly. Walking, doing yoga or strength training can help lower your risk for many medical conditions.
  • Weight-bearing exercises can strengthen your bones and muscles.
  • Eating a healthy diet. Foods like fruits, vegetables, lean meats and whole grains should make up the bulk of your diet. Avoid lots of salt or sugar and limit your consumption of alcohol.

A note from Cleveland Clinic

Going through menopause can be uncomfortable and present new challenges and health concerns. Speak with your healthcare provider about any symptoms you feel or questions you have. They can help make sure you are supported through this time and get the care you need.

Last reviewed by a Cleveland Clinic medical professional on 10/05/2021.

References

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What Happens During An Estrogen Test

Estrogens can be tested in blood, urine, or saliva. Blood or urine is usually tested in doctor’s office or lab. Saliva tests can be done at home.

For a blood test:

A health care professional will take a blood sample from a vein in your arm, using a small needle.

After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.

For a urine test:

Your health care provider may ask you to collect all urine passed in a 24-hour period. This is called a 24-hour urine sample test. For this test, your health care provider or a laboratory professional will give you a container to collect your urine and instructions on how to collect and store your samples. A 24-hour urine sample test generally includes the following steps:

  • Empty your bladder in the morning and flush that urine down. Do not collect this urine. Record the time.
  • For the next 24 hours, save all your urine passed in the container provided.
  • Store your urine container in the refrigerator or a cooler with ice.
  • Return the sample container to your health provider’s office or the laboratory as instructed.

For an at-home saliva test, talk your health care provider. He or she can tell you which kit to use and how to prepare and collect your sample.

When Do Estradiol Levels Go Down After Menopause

Estrogen Dominance

There can be other reasons for low estradiol, including excessive exercise, low body fat, and diminished ovarian reserve. However, estradiol levels do tend to drop over time. During the first 2 to 5 years following menopause or ovarian failure, blood levels of estradiol drop to an average range of about 25 to 35 pg/ml.

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What Causes A Low Estrogen Level

There are several possible reasons why a woman might experience low estrogen production or levels.

First, if there is a low estradiol level coupled with high FSH levels and high LH levels, this can indicate a condition known as premature ovarian failure or primary ovarian insufficiency. This means that, even with proper hormonal stimulation, the ovaries are failing to produce a normal amount of estradiol. This can sometimes be due to a genetic condition, such as Turner syndrome, an autoimmune disorder, or exposure to certain toxins.

Second, if there is a low estradiol level coupled with normal or low FSH and LH levels, this can be due to a condition known as hypogonadotropic hypogonadism. This condition can occur because of severe stress, excessive alcohol intake, excessive exercise, or a problem with the pituitary gland in the brainâwhich stimulates the production of FSH and LH hormones.

Can A Low Estrogen Level Affect Pregnancy

Certain conditions associated with low estrogen levels can make it harder to get pregnant. One condition, known as primary ovarian insufficiency, occurs when ovarian function declines even though a woman hasnât yet entered menopause. Sometimes this is due to a genetic condition, but it is thought that up to 90% of women with primary ovarian insufficiency do not have an identified cause.

Women who have had cancer and received chemotherapy are at risk for primary ovarian insufficiency because chemotherapeutic medicines can cause the death of egg cellsâwhich are needed for conception.

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How Much Estrogen Should You Have During Menopause

The experience of menopause can be different for every woman. Although many women will suffer the same symptoms, such as vaginal dryness, itchy skin, digestive problems, and depression, the extent and severity of the symptoms will often vary.

Most menopause symptoms are caused by hormonal imbalances in the body. Hormones help to regulate many of the body’s functions. One hormone that is affected during menopause is estrogen. Estrogen helps to regulate the menstrual cycle and fluid and salt retention. The extent and severity of your individual menopause symptoms can depend on how greatly your estrogen levels fluctuate during menopause, but many women wonder if there is an ideallevel of estrogenfor which they should aim. Continue reading to find out more about estrogen levels during menopause.

Estrogen Levels For People With Regular Cycles Not Using Hormonal Birth Control

Natural Solutions for Getting Your Hormones Back in Balance After Menopause

Estradiol levels in the blood can range considerably across the cycle. Whatâs ânormalâ can vary based on the lab you go to, where you live, your ancestry, and the testing technique. So you should always interpret your lab results with this in mind, but you can use these reference points below.

  • Early follicular phase: 20-150 pg/mL

  • Midcycle peak: 40-350 pg/mL

  • Luteal phase: 30-450 pg/mL

People under 15 years old and people who are postmenopausal generally have lower levels .

Estrogen levels can differ dramatically from cycle to cycle, but also be very different from person to person .

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Stage : Follicular Phase = Increasing Estrogen

Estradiol is mostly made within the ovaries. In the first part of the cycleâthe follicular phase, from the start of your period until ovulationâestradiol is produced from sacs that contain your eggs, called follicles. Estradiol stimulates the growth and thickening of the endometrium .

Near the end of the first phase, estradiol levels peak, triggering the brain to release two hormones: a large surge of luteinizing hormone , and a smaller surge of follicle stimulating hormone . This then triggers ovulation. Just before ovulation, the follicle stops producing estradiol and its levels drop .

Perimenopause: Rocky Road To Menopause

What are the signs of perimenopause? You’re in your 40s, you wake up in a sweat at night, and your periods are erratic and often accompanied by heavy bleeding: Chances are, you’re going through perimenopause. Many women experience an array of symptoms as their hormones shift during the months or years leading up to menopause that is, the natural end of menstruation. Menopause is a point in time, but perimenopause is an extended transitional state. It’s also sometimes referred to as the menopausal transition, although technically, the transition ends 12 months earlier than perimenopause .

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Why Do I Need An Estradiol Test

Your doctor may order an estradiol test if female or male sex characteristics arent developing at the normal rate. An estradiol level thats higher than normal indicates that puberty is happening earlier than usual. This is a condition known as precocious puberty.

Lower levels of estradiol may indicate late puberty. The test can help your doctor find out if there are problems with your adrenal glands. It can also help determine if treatment for hypopituitarism, or decreased function of the pituitary gland, is working.

Your doctor may order estradiol testing to look for causes of:

Your doctor may also order an estradiol test if your menstrual cycle has stopped and youre having symptoms of menopause. During and after menopause, a womans body will gradually produce less estrogen and estradiol, contributing to the symptoms experienced during menopause. A test of your estradiol level can help your doctor determine if youre preparing to enter menopause or youre already going through the transition.

The estradiol test can also indicate how well the ovaries are working. Therefore, your doctor may also order this test if you have symptoms of an ovarian tumor. The symptoms include:

Continuous And Sequential Regimens

Menopause &  Your Skin: How Your Skin Changes

Continuous combined MHT

The continuous/combined method of treatment evolved to improve patient satisfaction with hormones and avoid bleeding and other adverse cyclic symptoms. The continuous activity of progestin allows the use of lower doses that, by virtue of daily availability, inhibit endometrial growth. There is evidence that continuous progestin administration is highly protective against the development of endometrial hyperplasia and cancer.27 This approach involves the continuous daily use of the estrogenprogestin combinations listed in Table 2.

Table 2 Systemic MHT regimens

Combined continuous

Combipatch 50 µg estradiol + 0.1400.250 mg norethindrone acetate

The most common sequential method in the US involves estrogen administration with 0.625 mg of conjugated estrogens or 1.0 mg of micronized estradiol daily. A daily dose of 510 mg of medroxyprogesterone acetate is added for 14 days of every month. One-year randomized trial data indicate that the 5 mg dose protects the endometrium as well as the 10 mg dose.30 Oral estrogen may also be given with micronized progesterone, 200 mg nightly, for 12 days per month. This regimen has demonstrated satisfactory endometrial safety by biopsy criteria in 114 women followed for 3 years.31 Micronized progesterone has been administered vaginally as well, and appears effective in limited numbers of women.32

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What If I Have Low Lh Levels

If your results come back and show that your LH levels are below the normal range, this could be a sign of any of the following:

  • You may have problems with your pituitary gland, and/or
  • You may be malnourished or suffering from an eating disorder.

To improve your LH levels, there are a few different things you can do both naturally and medically.

In terms of natural solutions, a great place to start is by simply making healthy lifestyle choices. This includes getting plenty of sleep, eating a nutritious diet, avoiding alcohol and tobacco, and reducing overall stress levels. You can also try taking natural supplements like D-aspartic acid or Chasteberry, as some women have found these to be helpful for boosting LH levels.

If you have exhausted all natural options and still not having any luck, there are also medical treatments that you can try. This includes estrogen and progesterone replacement therapy, agonist and antagonist of gonadotropin releasing hormone agonists and antagonists, gonadotropins, and human chorionic gonadotropin injections to stimulate ovulation. Again, your doctor will have a better understanding of your background and can speak with you further about the best treatment option for your situation.

Medically Reviewed by Katerina Shkodzik, M.D., OB-GYN

Dr. Katerina Shkodzik is a certified OB-GYN with a special focus on reproductive endocrinology and infertility issues. She has been practising since 2015.

Additional Tips On Menopause And Hormone Levels

If you belong to the category of women who like to prepare in advance, and take care of health to provide comfortable living even in the 60s and 70s, you might find helpful the next tips on controlling the levels. Note, these are basic recommendations, a previous consultation with a doctor is a must.

  • Take vitamins. Calcium and Vitamin D will save your bones from injuries. Whenever hormone levels during menopause start fluctuating, the overall health deteriorates, and there is a big risk of breaking a bone. So, vitamins and menopause supplements will give another support
  • Medical examinations. Some women think that if there is no menstruation, so there is no point to go to the gynecologist. On the contrary, your visits should become regular. With age, ladies are more predisposed to diseases. So, for example, they can find out about the development of malignant tumors and save precious time on treatment. Note, hormone levels in menopause changes are normal but they may lead to negative consequences
  • Exercise. No need to go crazy over the gym or CrossFit for weight loss. Aerobics and swimming can become your best friends whenever hormone levels after menopause provoke hot flashes or sleep disturbances. Once you spent an hour on swimming, there are fewer chances your body will not be able to fall asleep
  • Beware of osteoporosis. This is a common disease during the climax. Ladies may lack calcium, and after that, this silent killer will lead to fatal consequences

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Alternative Treatments For Hot Flushes

For women who wish to avoid pharmacologic therapy, behavioral methods may be employed. These are usually effective for women with mild to moderate symptoms. Paced respiration has been shown to be effective in one small randomized trial. Other complementary and alternative treatments have been suggested, but none have demonstrated consistent efficacy.5, 121, 122 At best, these treatments have not demonstrated harm in most of the clinical trials performed to date.

Several non-hormonal treatments are accumulating medical evidence for efficacy that is less than estrogen, but acceptable for many patients. These are gabapentin, venlafaxine and escitalopram . None of these medications are FDA approved for this use. A brief summary is provided in the Table 4.

Table 4 Non-hormonal medication options for vasomotor symptoms

Medication

Days

Loss of libido, anorgasmia, possible weight gain

For women who cannot tolerate these alternatives, there are other medications that have demonstrated mixed efficacy in small trials. Transdermal clonidine, at a 100 g dose once weekly, has been shown to have efficacy.125, 126 Side-effects include postural hypotension. It may be prudent to begin with a lower dosage or even apply a half-sized patch at first. A modest impact can be expected.

Natural therapies

Phytoestrogens

Dehydroepiandrosterone

Do People In Postmenopause Lose Interest In Sex

Natural Hormone Therapy Before Menopause (Perimenopause or Premenopause)

No, not all people lose interest in sex after menopause. Vaginal dryness and discomfort during sex can make sex less pleasurable. Using a vaginal lubricant can help with dryness. Some people are less interested in sex because of other symptoms like depression or feeling tired. If your feelings about sex have changed, ask your healthcare provider for help.

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What You Need To Know About Your Hormones After Menopause

Have you ever wondered about your hormones after menopause…

  • Is your body still making hormones after menopause?
  • Which hormones decrease after menopause?
  • What hormones are needed after menopause?
  • Are hormones produced by the ovaries after menopause?
  • Do you need to worry about balancing your hormones after menopause?
  • Can hormones help you with weight loss after menopause?
  • What’s the best postmenopausal diet?

Get the answers to all these questions

and find out exactly how you can maximize those postmenopausal hormones for massive anti-aging and health-protective benefits in the video above.

Why Do Estrogen Levels Fall

There are many reasons why estrogen levels fall, including:

  • Hypogonadism
  • Anorexia nervosa
  • Extreme exercise or training

Drugs that block estrogen include clomiphene, which tricks the body into thinking it has decreased levels of estrogen. Also, women experience low levels of estrogen immediately after childbirth and also during breastfeeding.

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After Your Period Stops

The permanent end of menstrual periods doesnt necessarily mean the end of bothersome menopause symptoms, however.

The symptoms typically associated with menopause, like hot flashes and mood swings, can occur for some time both before and after that point.

Theres a window of about eight years in which women can feel those flashes and sweats, Dr. Audlin says.

Women who have reached menopause can expect menopause symptoms to become worse than they were during perimenopause, the 2- to 10-year stage leading up to the permanent end of menstruation. Experts dont know exactly why this happens, but its believed to be related to the hypothalamus, the portion of the brain that regulates temperature.

The hypothalamus is acutely responsive to estrogens, Audlin says. Leading up to menopause, your estrogen levels fluctuate. When theyre high, you dont have symptoms. But when you go into menopause and theres a complete lack of estrogen, you start to notice those symptoms more.

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