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What Does Progesterone Cream Do For Menopause

Why Do People Use Progesterone

How To Use Progesterone Cream for Hormonal Imbalances, PMS & Menopause Symptoms in Women

Over-the-counter progesterone cream has been marketed as a treatment for menopausal symptoms, including:

The progesterone in these creams can effectively travel through the skin and into the bloodstream, according to research. In one study, menopausal women used 40 milligrams of cream twice daily, placing it on their arm, thigh, breast, or abdomen. Their blood levels of progesterone were as high as when they took progesterone capsules by mouth.

Progesterone May Also Deliver Some Cognitive Benefits

During menopause, many people describe a fogginess in their thinking, along with some memory problems.

Theres some evidence that progesterone may protect against cognitive decline if hormone replacement therapy starts early in the menopause process.

Some researchers found that progesterone improved visual and verbal memory for people in menopause.

However, the evidence isnt clear-cut. Some studies , for example, found no protective cognitive benefit to progesterone at all.

In any case, its important to note that theres no evidence that progesterone harms your thinking abilities.

  • vaginal bleeding

Progesterone isnt recommended for everyone. Talk to your healthcare provider about alternatives to progesterone if you:

  • are over 60 years old
  • have been menopausal for longer than 10 years
  • have a personal or family history of breast cancer
  • are at a higher risk for dementia, heart attack, stroke, blood clots, osteoporosis, or liver disease

Progesterone At Work In Your Body

To understand what progesterone does inside the human body, you should recognize that the hormone is important for the processes of ovulation and menstruation. Beyond that, it plays a large role in preparing for and maintaining pregnancies and keeping sex drives high. The ovary releases progesterone roughly two weeks after a woman has begun a menstrual cycle. Its function is to trigger the release of proteins that are essential for the endometrium, or lining of the uterus, to handle pregnancy. These proteins make it possible for the endometrium to hold onto a fertilized egg .

If a fertilized egg successfully implants, then the placenta produces more progesterone. Normally, a woman experiences about 20-25 mg of progesterone during her cycle, but during pregnancy, the levels increase to 10 times that . The body needs the increased amount of progesterone to both prevent the release of other eggs and foster the growth of breast-milk glands .

Reportedly, progesterone creams have the same chemical makeup that the hormone progesterone has. Therefore, when we talk about what progesterone does in the body, manufacturers of progesterone cream want you to believe the same can be applied to their products. The only difference is how the cream and the hormone are sent through an individual’s system. According to label directions, in order to work properly, the cream must be absorbed through the skin into the body .

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Special Precautions & Warnings

Pregnancy and breast-feedingLIKELY SAFELIKELY UNSAFE

There is not enough reliable information about the safety of taking progesterone if you are breast-feeding. Stay on the safe side and avoid use.

Arterial disease: Don’t use progesterone if you have arterial disease.

Breast cancer: Avoid use unless you are directed to do so by your healthcare provider.

Depression: Get your healthcare provider’s advice first before using progesterone if you have major depression now or a history of major depression.

Liver disease: Progesterone might make liver disease worse. Don’t use it.

Vaginal bleeding: If you have undiagnosed vaginal bleeding, don’t use progesterone.

Symptoms Of Progesterone Overdose

Progesterone Cream

Continuous usage of progesterone higher than the amount recommend will result in a buildup of progesterone levels in the body. As progesterone levels build up, you may experience a variety of negative side effects:

Excessive progesterone use is associated with an increased risk of venous thromboembolism, or blood clots in the legs, arms, or groin. This risk appears to be even greater for women with preexisting factors for blood clots, including obesity, fractures, or immobility. Thankfully, studies suggest that this risk mainly applies to those taking orally administered progesterone. Transdermal or topical forms of progesterone have shown little to no effect on prothrombotic substances.13 Other potential symptoms of taking too much progesterone include:

  • Swelling in the extremities
  • Vaginal discharge
  • Problems urinating14

Some women also report developing PMS-like symptoms. You may also experience oily skin, sudden acne breakouts, and hirsutism . Most doctors also recommend alternating where you apply the progesterone cream as repeatedly applying the cream to the same area of skin can lead to irritation.4

Many women report less severe side effects when using naturally derived progesterone as opposed to synthetic products. General side effects may occur when starting progesterone and subside over time.15 However, if side effects persist or if you experience serious side effects that disrupt your quality of life, contact your doctor immediately.

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Custom Compounded Hormone Creams

Researchers looked at the benefits of custom compounded progesterone creams made from plant-based hormones, which are biochemically similar to the hormones produced in the body . A custom compounded preparation may contain progesterone as well as other hormones in different proportions to match with the unique medical needs of a woman.

Custom compounded bioidentical hormones have become widely accepted over the years, particularly after a major government-backed study called the Womens Health Initiative found a linkage between several life threatening conditions and conventional HRT .

A number of well-designed research studies have shown that custom compounded bioidentical hormone preparations, including progesterone cream, actually work. According to the researchers, these compounds can make a significant improvement in a womans quality of life.

Many doctors now agree that individualized hormone preparations, including progesterone creams, are just what women need to alleviate their menopause symptoms.

What Are Some Commonly Used Postmenopausal Hormones

The following list provides the names of some, but not all, postmenopausal hormones.


  • Pills, Brand names: Cenestin®, Estinyl®, Estrace®, Menest®, Ogen®, Premarin®, Femtrace®.
  • Creams, Brand names: Estrace®, Ogen®, Premarin®.
  • Vaginal ring,Brand names: Estring®, Femring® .
  • Vaginal tablet, Brand names: Vagifem®. Imvexxy®
  • Patch, Brand names: Alora®, Climara®, Minivelle®, Estraderm®, Vivelle®, Vivelle-Dot®, Menostar®.
  • Spray, Brand name: Evamist®.
  • Modest improvement in joint pains.
  • Lower death rate for women who take hormone therapy in their 50s.

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Getting The Right Support After Menopause

For women who want to ease symptoms of menopause while protecting their health, bioidentical progesterone can be an essential part of treatment. However, each woman is unique, and the treatment you choose should be guided by your individual needs and preferences. By working with a practitioner who specializes in bioidentical hormone replacement therapy, such as those in the BodyLogicMD network, you can develop a customized plan designed specifically for you. With the right support, you can ensure that you feel your best as you enter this new stage in life.

If you are considering bioidentical hormone replacement therapy, BodyLogicMD-affiliated practitioners offer the tailored care you need. Our network is comprised of top medical professionals who specialize in helping patients find wellness through hormonal therapies. By taking an integrative approach to treatment, our practitioners will work with you to achieve your health goals and give you the resources you need to thrive. Get started on a customized treatment plan designed to fit your lifestyle and allow you to reach optimal wellness. To begin your journey, contact a local practitioner within the BodyLogicMD network to schedule your first appointment, or take our Hormone Balance Quiz today.

Disclaimer: These statements have not been evaluated by the Food and Drug Administration. All content on this website is for informational purposes only. The content is not intended diagnose, treat, cure, or prevent diseases.

A Note From Cleveland Clinic

How to Apply Progesterone Creme!

The decision to take hormone therapy needs to be a very personalized one. Hormone therapy is not for everyone. Discuss the risks and benefits of hormone therapy with your healthcare provider at an office visit specifically dedicated for this conversation. Youll need the time to address all the issues and answer questions in order to arrive at a decision that is best for you. Factors considered should be your age, family history, personal medical history and the severity of your menopausal symptoms.

Be sure to talk about the pros and cons of the different types and forms of HT as well as non-hormonal options such as dietary changes, exercise and weight management, meditation and alternative options.

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How Much Progesterone Should I Take After Menopause

The best way to answer this question is to speak with your doctor. Your healthcare provider can review your health history and symptoms to determine the best progesterone dose for your unique concerns and needs.

In general, with hormones like estrogen and progesterone, the goal should be to address your symptoms by taking the lowest dosage for the shortest amount of time possible.

What Are Natural Progesterone Creams Used For

Progesterone creams are most often used to relieve symptoms of menopause. Menopause is a normal condition that every woman goes through during which menstruation ends, marking the end of a womans ability to have children. Physiologically, menopause is caused by a significant decline in the bodys production of estrogen and progesterone.2 This is also followed by an increase in follicle stimulating hormone and luteinizing hormone .3

This sudden hormonal imbalance results in a variety of severe emotional and physical symptoms.

Progesterone cream aims to reduce or relieve some of menopause and perimenopause symptoms. It may help to:

  • Reduce hot flashes
  • Improve skin dryness, thinning, and wrinkling4

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Concerns About Progesterone Cream Use

You can’t actually know how much progesterone you are getting without having a whole-blood progesterone test. Because of this and the following concerns, some experts are concerned about use of over-the-counter progesterone cream.footnote 2

  • If it is absorbing well. Progesterone treatment has risks. It has been linked to headaches and dangerous blood clots in a small number of women. This is why progesterone is usually a prescription hormone and is not safe for women with certain health risks.footnote 2
  • If it is not absorbing well. If you are taking estrogen , you also need to have enough progesterone to prevent the estrogen from causing uterine cancer. Using a poorly absorbed progesterone cream while taking estrogen does not protect you from uterine cancer.footnote 1

Natural Ways To Boost Progesterone During Menopause

Do You Have Low Progesterone Symptoms?

Many women will find themselves with dipping levels of progesterone during menopause. Regular doctor’s visits and routine check-ups are recommended for women because it can easily be established though blood tests whether women are experiencing a hormonal imbalance. There are numerous progesterone aids that are now available to help women regulate their progesterone levels. By leveling progesterone levels women can fight the most common symptoms of menopause, including mood swings, hot flashes, night sweats and vaginal dryness. Read more about natural ways to balance progesterone levels.

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Progesterone Cream And Menopause

People who promote progesterone cream swear it has a multitude of purposes. Of these many functions, the most popular seems to be for women experiencing menopause. Menopausal women contend with depression, hot flashes, moodiness, night sweats, stress, vaginal dryness and weight gain. If only a cream could make all these symptoms go away.

After a woman’s body enters menopause, progesterone levels are known to decrease. Because of this lower level of the hormone, supplements are often needed to compensate. While some women use a combination of estrogen and progesterone hormone replacement therapy, others opt for progesterone cream . As we have mentioned previously, progesterone cream is thought to have less side effects than synthetic progesterone while still providing many of the same benefits.

The goal is simple: to provide relief against the uncomfortable symptoms of menopause. Some studies have found that women who use progesterone cream were able to reduce their hot flashes . It’s also said that progesterone cream may help bone density in menopausal women who are at risk for bone loss, but some studies disagree. One found that after a 12-month trial, the progesterone cream did not prevent bone loss and did not increase bone density .

To learn more about progesterone, visit the links on the following page.

What Is Progesterone Cream

Progesterone creams are drugs used to complement progesterone in the body. There are two types:

Synthetic progesterone creams. This type of progesterone cream contains concentrations of synthetically produced progesterone, also known as progestin. Progestin causes some or all of the biological effects of endogenous progesterone.

Plant-derived progesterone creams. United States Pharmacopia natural progesterone cream – or bioidentical progesterone cream – is derived from plant sterols stigmasterol and diosgenin, which are isolated from soy and wild Mexican yam, respectively. In laboratories, these sterols are converted to pregnenolone, a principal precursor to steroid hormones, and then to progesterone.

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Does Progesterone Cream Have Any Health Benefits

There is some evidence that suggests it might progesterone cream can have some health benefits. Some studies have suggested that it can improve:

  • Hot flushes and night sweats
  • Endometriosis, a condition that can cause pain, abnormal bleeding, and disturbances to the digestive tract
  • The elasticity of the skin and appearance of wrinkles

Unfortunately, results from research that has been conducted into progesterone cream arent clear cut because theres currently not enough data to draw conclusions.

What are the benefits of proper progesterone medications? there are many potential health effects of taking progesterone-containing medications, such as progesterone-containing pills and vaginal pessaries. Progesterone has been shown to:

  • Improves symptoms of menopause progesterone is one of the options used in hormone-replacement therapy and can improve symptoms such as hot flushes and night sweats
  • Increase bone strength progesterone can help your body build bones, which can in turn reduce the risk of getting fractures
  • Reduce inflammation inflammation is your bodys natural reaction to an injury or infection. However, inflammation also causes pain and reduced function to the part of the body that is affected
  • Reduce blood pressurehigh blood pressure can damage your heart, kidneys, blood vessels, and other organs
  • Reduce obesity a higher level of progesterone has possibly been linked to a lower body weight

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Will Topical Progesterone Work For You

Incredible Benefits of Progesterone Cream For Menopause & Much More

Severe menopause symptoms can crush the joy out of everyday life and magnify your fears about how your body is changing. But it doesnt have to be this way, and you dont have to resort to extreme measures.

Even with dramatic hormone fluctuations in perimenopause, your body has the ability to adapt to the changes. Many women get good results with topical progesterone over time without having to worry about side effects. The best topical progesterone remedies have special application instructions that mimic the way progesterone rises and falls during the average menstrual cycle.

We each have a different hormonal profile which means our symptom experience is unique too. As with many natural remedies, the best way to know if topical progesterone will ease your specific menopause symptoms is to try it for several months to measure its effectiveness.

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When Do I Use Progesterone Cream

Women use progesterone creams at different times, depending on their hormonal situations. The most common dosage involves using the cream during the second half of the menstrual cycle, which is when progesterone levels should be higher. After menopause, women usually use the progesterone cream continuously.

Progesterone And Lipid Metabolism

Overall, estrogen therapy is associated with positive long-term effects on the lipoprotein profile of postmenopausal women, although it should be noted that this effect was found more commonly for orally administered estrogen.

In contrast to these findings, synthetic gestagens if combined with estrogens reduce HDL-C concentrations. A direct comparison with synthetic gestagens showed that micronized progesterone has fewer negative effects on HDL-C metabolites compared to synthetic gestagens. Saarikoski et al. carried out a study in 80 perimenopausal women treated for functional menometrorrhagia. The women were divided into 2 groups to receive either 300mg/day oral micronized progesterone for 10 days per cycle or 15mg/day norethisterone for 10 days per cycle over 6 consecutive cycles. The study showed that HDL-C levels remained stable with progesterone, but there was marked decrease in HDL-C levels in the norethisterone group . The previously mentioned PEPI trial also showed that, in significant contrast to medroxyprogesterone used in the other arms of the study, progesterone has the least impact on the positive effect on HDL-C caused by estrogens .

Changes in HDL-C levels after estrogen monotherapy, estrogen and progesterone administration, cyclical administration of estrogen with MPA , continuous administration of estrogen with MPA, and placebo . CEE: conjugated equine estrogen.

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Progesterone Is Given Along With Hrt

Progesterone is frequently given to women who are on hormone replacement therapy. HRT contains estrogen, and although it can mitigate some side effects of menopause such as hot flashes, vaginal dryness, and mood swings, and it increase risks for some diseases. Progesterone is given, because doctors believe that it will treat symptoms, and because it lowers a woman’s risk of getting uterine cancer.

Tolerability And Safety Of Progesterone

Natural Woman Progesterone Cream

As shown in , progesterone is associated with a number of partial side effects which clearly differentiate it from all synthetic gestagens. This profile outlines the individual effects on different parameters in the human body.

Table 2Progesterone and synthetic gestagens and their properties (mod. nach .


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Where Can You Buy Progesterone

Progesterone cream can be bought online or in health stores.

Prescription medications medicines containing progesterone is mostly available on prescription. To get your supply on prescription, you need to make an appointment with a GP who will assess whether progesterone treatment is suitable for you. If this is the case, then you will receive a prescription. Then, you can get your supply of progesterone from a pharmacy.

We do stock some medicines that contain progesterone these products are:

  • Hormone replacement therapy HRT treatment can contain progesterone, oestrogen, or a combination of both hormones
  • Contraceptive pills regular contraceptive pills can contain just progesterone or a combination of oestrogen and progesterone

You should make an appointment with your doctor if you are worried about any conditions or issues that have been discussed in this article.

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