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Does Egg Freezing Cause Early Menopause

Does Age Play A Role In Fertility After Cancer

Mache Seibel, MD Egg Freezing for Perimenopause or Early Menopause Pregnancy.

Yes, age plays an important role in a womans fertility. You are born with a fixed number of eggs that diminish as you age. When you no longer have any eggs in your ovaries or when your ovaries lose the ability to release eggs, you have entered menopause. Cancer treatments can accelerate this process by damaging your egg supply, which can cause premature ovarian failure and impact fertility.

Fertility Treatment And Early Menopause: Myth And Reality

Female infertility is a dire issue because it not only brings physical trauma but emotional stress and depression too. There are several myths and misconceptions that are associated with infertility. Many times, lack of awareness can cause patients to overlook the reality and they end up aggravating their problems. It is important that they discuss such issues openly with their infertility specialist and get clarity on them.

One big question that patients come across is whether infertility treatment pushes them towards early menopause. The question is raised on the basis of the notion that treatments like IVF involve ovarian stimulation. This means that each cycle involves production of multiple eggs. Logically speaking, this would result in depletion of egg and the woman may end up having early menopause.

The patient might actually think that the treatment may make things worse for her. The fear may be even greater if she undergoes multiple cycles as this translates to loss of greater number of eggs in each cycle. It is important to understand whether her long-term fertility would be compromised with treatment so that she decides what is best for her.

Fertility Treatment and Early Menopause: Myth or Reality

The Final Word

Is It Safe To Get Pregnant And/or Undergo In Vitro Fertilization After Breast Cancer

IVF does temporarily raise estrogen levels to above normal, which theoretically could cause breast cancer cells to grow and multiply. Some infertility treatments use hormones to mature multiple eggs during a menstrual cycle. This is called standard stimulation. These hormones can raise a woman’s estrogen levels, which is a special concern for breast cancer patients. Many breast tumors are sensitive to estrogen, and higher estrogen levels may speed the growth of cancer cells.

Hormones are not needed for all infertility treatments, but they are usually needed for embryo freezing and egg freezing. Some doctors may approve standard stimulation for breast cancer patients if chemotherapy starts immediately afterward. Breast cancer patients can also choose from alternative stimulation methods that may be safer. It is important to consult with both your oncologist and a reproductive endocrinologist to learn about all of your options and make the best treatment decision for you.

Estrogen levels are also high during pregnancy, but not as high as peak levels during IVF. Studies to date do not show that pregnancy after breast cancer triggers cancer recurrence.

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Heart & Cardiovascular Health

Women experiencing a premature or early menopause may have an increased risk of heart disease, compared to women who reach menopause at the expected age, although this remains controversial.

A recent study suggested women with premature or early menopause may also be at greater risk of stroke. This might be because of the loss of the beneficial effects of oestrogen on the blood vessels and the lipid profile of younger women. Further understanding in this area is still needed.

There are also other cardiovascular disease risk factors, such as family history, high blood pressure and high cholesterol levels.

A healthy lifestyle can help reduce the risk of cardiovascular and heart problems. Stopping smoking, eating a healthy, balanced diet with plenty of fruit and vegetables, maintaining a healthy body weight and doing regular physical activity reduces the risk of heart disease in women of all ages.

There is some evidence that suggests menopausal hormone therapy, or MHT use in women with premature or early menopause reduces the risk of cardiovascular disease.

It is recommended that you have annual monitoring of blood pressure, weight, smoking status and cholesterol and sugar levels, as well as a discussion with your doctor, to help keep a check on your risks of cardiovascular disease.

Now For The Question Of The Hour: How Much Does Egg Freezing Cost

Early Menopause and Female Infertility

Freezing your eggs and then using them in the future, if you choose to, involves several steps from doing the egg retrieval and flash-freezing now to thawing the eggs and fertilizing them with sperm for in vitro fertilization later.

Here’s how all the associated costs break down:

  • General procedure: The exact price of egg freezing varies depending on several factors, including your clinic and region, but the price range for the procedure alone is usually between $5,000 and $10,000 per cycle.
  • Fertility medication: When considering the costs of ovarian-stimulation injections and medications, the price of one egg freezing cycle goes up to around $10,000-$12,000.
  • Storage fees: The above procedure cost usually includes one year of storage for your eggs at a long-term or independent storage facility, which costs about $500-$1,000 annually .
  • Donor sperm: If you need donor sperm in order to turn your frozen eggs into embryos when you’re ready to try to conceive, that can range from $300 to $4,000 depending on whether youre using a non-directed or directed donor anonymous or known donor .
  • Embryo creation: Thawing the eggs, undergoing intracytoplasmic sperm injection , and doing genetic testing of the embryos may run you $5,000-$8,000.
  • IVF after egg freezing: IVF treatments to use those embryos are closer to $11,000-$12,000.

Since the costs can vary from person to person , here are two real-world examples:

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Symptoms Of Early Menopause

The main symptom of early menopause is periods becoming infrequent or stopping altogether without any other reason .

Some women may also get other typical menopausal symptoms, including:

Read more about the symptoms of the menopause.

Women who go through early menopause also have an increased risk of osteoporosis and cardiovascular disease because of their lowered oestrogen hormone levels.

Leading Into Infertile Years

Throughout womens reproductive years, the ovaries are responsible for producing the reproductive hormones necessary for healthy menstrual cycles, specifically estrogen and progesterone.

With age, ovarian hormone production declines, and estrogen and progesterone levels fluctuate drastically as women enter the perimenopausal transition.

Once perimenopause begins, it becomes challenging to become pregnant. Menstrual cycles are irregular, and your ovaries release fewer eggs, making it difficult to time ovulation with conception efforts.

Accordingly, because age is the most critical factor involved in getting pregnant with ones own eggs, women entering perimenopause early should promptly research alternative options to maximize their chances of conceiving.

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Eating Meat And Animal By

You dont have to adopt a total vegan lifestyle, but the reality is that animals are eating food products grown in contaminated soil and watered with contaminated water. Some of them are further contaminated via the heavy use of antibiotics and hormones. Fish are swimming around in polluted lakes, rivers and oceans. Thus, meat, fish and dairy products can contain PCBs, phthalates, heavy metals, hormones and other chemicals known to cause early menopause. Eat organic meats and animal by-products or those grown by local farmers who can verify the type of feed and lifestyle they enjoy. Try going vegetarian at least once or twice a week to reduce your total intake of potential contaminants it will be good for your body too.

How Is My Identity Protected

Doctor explains root causes for early menopause

You will be assigned a code number known only by the members of our team. All blood studies and cervical cultures will be processed under this number rather than your name. The surgical record will also list this number rather than your name. All records are kept in a locked file cabinet.

The couple receiving your eggs signs a consent form stating that they understand that the egg donation is anonymous, and it will not be possible for them or any children born as a result of this therapy to contact you in the future. During the selection process, the recipient couple will be given general information regarding your height, weight, complexion, ethnicity and family medical history.

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Criteria To Define Early Ovarian Ageing

Due to lack of a uniform criterion, poor response to ovarian stimulation was taken as a sign of EOA, making this entity as a retrospective diagnosis. Recently, the European Society of Human Reproduction and Embryology issued a consensus on the definition of poor ovarian reserve for ovarian stimulation during IVF_ process as the Bologna criteria for poor ovarian response . At least two out of the three criteria are needed to define poor ovarian reserve .

  • Advanced maternal age or any other risk factor for POR.

  • A previous POR .

  • An abnormal ovarian reserve test .

  • This poor ovarian reserve in early thirties is synonymous with EOA.

    Treatments For Early Menopause

    The main treatment for early menopause is either the combined contraceptive pill or HRT to make up for your missing hormones.

    A GP will probably recommend you take this treatment until at least the age of natural menopause , to give you some protection from osteoporosis and other conditions that can develop after the menopause.

    If you have had certain types of cancer, such as certain types of breast cancer, you may not be able to have hormonal treatment.

    The GP will talk to you about other treatment options and lifestyle changes you can make to help protect your health.

    If you’re still getting symptoms, the GP can refer you to a specialist menopause centre.

    Going through the menopause early can be difficult and upsetting.

    Permanent early menopause will affect your ability to have children naturally.

    You may still be able to have children by using IVF and donated eggs from another woman, or using your own eggs if you had some stored. Surrogacy and adoption may also be options for you.

    Counselling and support groups may be helpful.

    Here are some you may want to try:

    Page last reviewed: 02 February 2021 Next review due: 02 February 2024

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    How To Detect Fibroids After Menopause Symptoms And Methods Of Diagnosis

    The medical literature describes many symptoms of fibroids after menopause, but, most often they are talking about three of them:

    • Increased profuse menstrual bleeding.
    • Large fibroids can put pressure on the bladder or rectum, leading to impaired urination, problems with stool.
    • Stomach enlargement. Many women ignore this symptom because they believe that they just gained weight.

    Other possible manifestations: pain in the lower abdomen, lower back, legs, pain during intercourse. Although you need to remember that these signs are nonspecific and can often indicate other diseases

    Reality: Its Important That Youre Emotionally Prepared For Fertility Testing And Treatments

    Menopause Signs and Symptoms

    Youre going to have a stronger emotional reaction to the results of a fertility hormone check than you would to the results of a cholesterol check, and understandably so. The ability to have a family is important to many people, and for women that ability is often tied up with all sorts of ideas about femininity, fitness, and expectations for the future.

    Preparing emotionally also means considering things youve never thought of before. Before egg freezing in particular, I recommend women consider seeing a fertility preservation psychologist to help them think through the implications. A good psychologist will guide you through questions like Where will the eggs go if something happens to me? or What will I do if I end up not needing them?

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    What Happens On The Day Of Egg Retrieval

    You will need to come to the operating room area two hours before the scheduled time of egg collection. Please do not eat or drink anything after midnight the evening prior to the procedure. Please do not chew gum the morning of your retrieval.

    Immediately prior to beginning the egg retrieval, the anesthesiologist will give you medicine through an IV to induce sleep. You will be breathing on your own with supplemental oxygen.

    After the egg retrieval is completed, you will be taken to the recovery room for observation over a one- to two-hour period. You will then be released to go home. Since you received anesthesia, someone will be required to drive you home.

    You should be able to return to work the next day. We ask that you abstain from vaginal intercourse from a period of three days before to a period of four days after the egg retrieval. You will need to use a barrier contraceptive method such as condoms or a diaphragm until you get your period. After that, you may resume your current method of birth control.

    Ovulation And The Menstrual Cycle

    During their reproductive years, women have regular monthly menstrual periods because they ovulate regularly each month. Eggs mature inside of fluid-filled spheres called follicles. At the beginning of each menstrual cycle when a woman is having her period, a hormone produced in the pituitary gland, which is located in the brain, stimulates a group of follicles to grow more rapidly on both ovaries. The pituitary hormone that stimulates the ovaries is called follicle-stimulating hormone . Normally, only one of those follicles will reach maturity and release an egg the remainder gradually will stop growing and degenerate. Pregnancy results if the egg becomes fertilized and implants in the lining of the uterus . If pregnancy does not occur, the endometrium is shed as the menstrual flow and the cycle begins again. In their early teens, girls often have irregular ovulation resulting in irregular menstrual cycles, but by age 16 they should have established regular ovulation resulting in regular periods. A womans cycles will remain regular, 26 to 35 days, until her late 30s to early 40s when she may notice that her cycles become shorter. As time passes, she will begin to skip ovulation resulting in missed periods. Ultimately, periods become increasingly infrequent until they cease completely. When a woman has not had a menstrual period for 1 full year, she is said to be in menopause.

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    Do Cancer Survivors Have A Higher Rate Of Miscarriage

    This is primarily a concern for women who have had radiation to the pelvic area. Miscarriage, pre-term delivery and low birth-weight infants are more common in women who have received radiation to their uterus. A specialist can evaluate whether there is damage to your uterus. To date, research does not suggest a higher rate of miscarriage rate after exposure to chemotherapy or radiation to other parts of the body.

    How Do I Know If I Have Early Menopause

    Chemotherapy can cause premature menopause, infertility

    The first sign of early menopause is the alteration of the menstrual cycle and the absence of periods. Also, if you are trying to get pregnant without success, the cause of infertility may be related to ovarian failure.

    To confirm whether a woman really suffers from early menopause, it will be necessary to have a gynecological check-up and a hormonal examination.

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    How Cancer Treatment Can Affect Fertility

    Doctors may not be able to predict how female fertility will be affected. But your age and the planned treatment can help give an idea of your individual risk. Sometimes, it may be possible to reduce the effects of treatment on your fertility.

    Treatments can damage or affect:

    • the eggs in the ovaries
    • the pituitary gland and hormone levels
    • the womb, cervix or ovaries.

    Cancer and cancer treatment can also change how you feel about sex or make it physically difficult to have sex. We have more information about coping with sexual difficulties that may be useful.

    What Is Early Menopause

    Early menopause is the termination of reproductive activity in women under 40. The ovaries stop working, there is no ovulation, and eventually menstruation will disappear.

    This condition is also known as premature ovarian failure , which is a cause of infertility in 1% of women.

    The symptoms and consequences of early menopause are the same as those of menopausal women over 50.

    Below you have an index with the 10 points we are going to deal with in this article.

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    If I Froze Eggs Embryos Or Ovarian Tissue Prior To Cancer Treatments But I Never Use Them Or I Have Some That I Dont Plan To Use What Do I Do With Them

    If you choose not to use eggs, embryos or ovarian tissue, you generally have three choices:

    • Discard them
    • Donate them to research
    • Donate them to another person or couple who is trying to conceive

    This is a very personal decision. Generally, prior to freezing any of these tissues your fertility specialist will ask you to decide what you would like done in the event of your death, divorce or any other unforeseen circumstances. For example, if in the event of death you would like to leave frozen eggs or embryos to your partner or another family member, you would need to create an advance medical directive outlining these wishes. It is always recommended that you speak with a licensed professional counselor or social worker when considering your options. If your fertility center does not offer these services, you can seek out a medical social worker, faith leader or personal counselor. You may also consider speaking with a legal representative to discuss your rights and options.

    Treatments To Relieve Signs And Symptoms

    Does Menopause Cause Ageing Pain Ovary Early Pregnancy ...

    There is no treatment that can reverse or prevent premature menopause. However, women who have reached menopause do have treatment options that can help control unpleasant symptoms.

    Types of treatments for symptom relief include:

    • Hormone therapy: hormone therapy is available in different forms including pills, patches, transdermal sprays, or gels or creams. Localized hormone treatments are also available for intravaginal use. HT/ET is the most effective way to control symptoms like hot flashes and vaginal dryness. Because HT/ET has been associated with certain health risks , experts recommend using the lowest effective dose of hormone therapy for the shortest period of time necessary for symptom control.
    • Oral contraceptive pills are a form of HT that is sometimes used to help relieve menopausal symptoms.
    • Antidepressant medications: the selective serotonin reuptake inhibitors and related medications have been shown to be effective in controlling the symptoms of hot flashes in up to 60% of women.
    • Non-hormonal vaginal gels, creams, and lubricants can help prevent the symptoms of vaginal dryness.
    • Assisted reproductive technologies: in selected cases, pregnancy may be achieved using donor eggs in women with premature menopause.

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