What Causes Primary Ovarian Insufficiency
In about 90% of cases, the exact cause of POI is unknown.
Research shows that POI is related to problems with the follicles. Follicles are small sacs in your ovaries. Your eggs grow and mature inside them. One type of follicle problem is that you run out of working follicles earlier than normal. Another is that the follicles are not working properly. In most cases, the cause of the follicle problem is unknown. But sometimes the cause may be:
- Genetic disorders such as Fragile X syndrome and Turner syndrome
- A low number of follicles
- Autoimmune diseases, including thyroiditis and Addison disease
- Chemotherapy or radiation therapy
- Toxins, such as cigarette smoke, chemicals, and pesticides
Preparing For The Future
Not only can we store your IVF embryos for future use, but we can also harvest and store your own eggs. For example, if you know you want to have children someday, but arent ready just yet, we can collect and store your eggs so that you can have children via IVF when youre ready. Alternatively, if you know youre going to have chemotherapy or another treatment that could damage your fertility, we can collect your eggs before you have your treatment and store them so you can use them to get pregnant later.
Our team is here to help you grow your family. We know its emotionally challenging, and our compassionate staff provides gentle care while still maintaining honesty about your condition and options.
If youre struggling to get pregnant or know that you have premature ovarian failure, today for expert fertility testing and treatment.
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What Is Premature Ovarian Failure
Premature ovarian failure is clinically diagnosed when your ovaries stop releasing viable eggs before the age of 40, well before you reach menopause. Many factors contribute to premature ovarian failure, such as:
- Autoimmune diseases
- Infections, like the mumps
- Cancer treatments, like chemotherapy
You might not know that you have premature ovarian failure until you start trying to get pregnant without success. Remember, if youre under the age of 35, you should talk to a fertility specialist, like our compassionate and experienced doctors, Eliron Mor, MD, and Irene Wood, MD, here at the California Center for Reproductive Health if you dont get pregnant within 12 months of trying. If youre 35 or older, get help if youre not pregnant within six months.
However, you might also stop getting your periods or have menopause symptoms,
like hot flashes, night sweats, and mood changes.
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What Is Primary Ovarian Insufficiency
Primary ovarian insufficiency is a disorder that occurs when a womans ovaries stop functioning prematurely . In women with this condition, the ovaries stop producing eggs before age 40. The usual age for egg production to stop, known as menopause, is around 50.
When the ovaries stop functioning and stop producing eggs, they also no longer produce hormones including estrogen. Women with low estrogen levels are at an increased risk of certain health issues. Primary ovarian insufficiency is also known as premature ovarian failure. This diagnosis is currently called insufficiency rather than failure because the ovaries can intermittently function, begin releasing eggs, and even result in successful pregnancy.
How Is Mumps Treated
There is no treatment for mumps the disease must be allowed to run its course. Treatment focuses on treating symptoms to make the person as comfortable as possible. These treatment steps should be the following:
- Drink plenty of fluids.
- If the glands are swollen and causing discomfort, ice or heat packs can help ease the pain.
- Non-aspirin medications such acetaminophen and ibuprofen can be used to bring a fever under control and help with pain from swollen glands.
Do not give your child aspirin. Children with viruses such as mumps who take aspirin can develop Reyes Syndrome, a dangerous disease that causes liver failure, swelling of the brain, and even death.
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Who Can Still Get Pregnant
The bottom line is if you havent reached menopause defined as 12 straight months without a period you can still get pregnant. Dr. Bembry acknowledges that some women develop a false sense of security when they go off birth control and go for years without becoming pregnant.
Similarly, women with a history of infertility might assume they cant get pregnant in their 40s. The same goes for women with premature ovarian failure. While these patients may look like theyre menopausal, they can still ovulate and become pregnant.
Why Does Early Menopause Affect Fertility
Menopause is when you stop having periods and your ovaries no longer release eggs. This means that once youve gone through the menopause, youll be infertile or no longer able to get pregnant naturally.
Early menopause is when you go through the menopause between the ages of 40 and 45. If your menopause happens before the age of 40, its known as premature menopause . Most people go through the menopause between the ages of 45 and 55.
An early or premature menopause can happen naturally. Or it might be due to certain medical or surgical treatments youve had.
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What Other Problems Can Primary Ovarian Insufficiency Cause
Since POI causes you to have lower levels of certain hormones, you are at greater risk for other health conditions, including:
- Anxiety and depression. Hormonal changes caused by POI can contribute to anxiety or lead to depression.
- Dry eye syndrome and eye surface disease. Some women with POI have one of these eye conditions. Both can cause discomfort and may lead to blurred vision. If not treated, these conditions can cause permanent eye damage.
- Heart disease. Lower levels of estrogen can affect the muscles lining the arteries and can increase the buildup of cholesterol in the arteries. These factors increase your risk of atherosclerosis .
- Low thyroid function. This problem also is called hypothyroidism. The thyroid is a gland that makes hormones that control your body’s metabolism and energy level. Low levels thyroid hormones can affect your metabolism and can cause very low energy, mental sluggishness, and other symptoms.
- Osteoporosis. The hormone estrogen helps keep bones strong. Without enough estrogen, women with POI often develop osteoporosis. It is a bone disease that causes weak, brittle bones that are more likely to break.
You Can Still Get Pregnant In Perimenopausei Did
My husband, Aaron, and I had been trying for baby number two for over a year. After one intrauterine insemination , two unsuccessful rounds of IVF, countless hormones and endless stress and tears, we decided to defrost my frozen eggs. Six years prior, single after a series of bad breakups, I was certain I wanted to be a mom but uncertain Id find a partner. So I made an impulse purchase and signed up with a fertility clinic to freeze my eggs.
Our son turned out to be fairly easy to conceive. At 37, after one miscarriage and five months of trying, I became pregnant. When we decided to have a second child when I was 39, I thought conceiving this time around would be just as certain. It wasnt.
On Mothers Day, the day before my 40th birthday, we learned that our first round of IVF didnt work. My body and mind were exhausted. Balancing fertility drugs and treatments, caring for our toddler and recovering from three additional miscarriages in 10 months, I felt as though I were playing one of those carnival gamesI bopped one miscarriage over the head, only for another pregnancy loss or failed fertility treatment to pop up, leaving us no closer to a baby.
How was this happening to me? There were six sets of twins and a set of natural triplets in my fertile Midwest Jewish family. The running joke was that my mom looked at my dad to become pregnant. My body is failing our family, I told Aaron. Women much older than me are popping out babies everyday.
My FSH measured at 25.4.
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Can I Get Pregnant If I Have Premature Ovarian Failure
While possible, it is highly unlikely that youll be able to conceive through intercourse alone if you have ovarian failure. However, just because your ovaries arent releasing eggs, doesnt mean you cant get pregnant. You just need to explore your fertility treatment options and find the treatment that will work best for you.
Early Menopause And Fertility
Going through an early menopause can be tough enough. But losing your fertility before youre ready can be devastating.
Early menopause doesnt necessarily mean the end of the road for having children though. Here Ill go through all the key things you need to know about early menopause and fertility.
Risks Of Premature & Early Menopause
The risks of developing osteoporosis and cardiovascular disease are higher for women with premature or early menopause than for women reaching menopause at the expected age. For this reason, it is important that you seek advice and treatment from your doctor.
According to community studies, women who go through premature or early menopause without hormone treatment have a reduced life expectancy by about two years.
The advice below is based on current expert opinion, as there are no studies on women with premature or early menopause that establish which prevention strategies are effective.
About Dr Roohi Jeelani
Dr Roohi Jeelani is Director of Research and Education at Vios Fertility Institute in Chicago, Illinois. Dr Jeelani earned her medical degree from Ross University School of Medicine in Portsmouth, Dominica. She then completed a residency in Obstetrics and Gynecology and a fellowship in Reproductive Endocrinology and Infertility at Wayne State University, Detroit Medical Center, where she was awarded a Womens Reproductive Health NIH K12 Research Grant. She is board certified in Obstetrics and Gynecology.
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What Are The Causes Of Early Menopause
Early or premature menopause can happen for two reasons: follicle depletion or follicle dysfunction.
When these occur, eggs dont mature or get released, causing a womans period to stop. These processes are considered normal when they occur later in life. If they occur early, your doctor will likely check for an underlying cause.
Follicle depletion and dysfunction can happen for a variety of reasons:
- Aging. The risks of early menopause rise after age 35.
- Family history. Being related to women who have a history of early or premature menopause may raise your risk.
- Genetic disorders. Having abnormal chromosomes or genes, as occurs in Turner syndrome or Fragile X syndrome.
- Toxins. Exposure to chemotherapy drugs and radiation therapy used to treat cancer can affect onset of menopause.
- Autoimmune conditions. When the immune system mistakenly attacks the bodys hormone-producing organs, it can sometimes affect the ovaries.
- Infection. Having certain infections such as the mumps virus.
- Surgery. Procedures to remove the ovaries or uterus may cause early menopause.
Your doctor will ask you about your symptoms and your menstrual cycle.
They may also:
- ask about your history of exposure to toxins, such as chemotherapy and radiation treatments
- conduct a physical exam
- perform a pregnancy test
Early and premature menopause can increase your chance of developing other conditions. These include:
It’s Easy To Get The Care You Need
See a Premier Physician Network provider near you.
As you head toward the big change, keep in mind that diaper changes arent quite out of the picture just yet. You can still get pregnant during perimenopause defined as the years leading up to your final period.
This menopausal transition brings unpredictable ovulation cycles as estrogen and progesterone hormone levels go up and down. During these years of yo-yoing hormone levels, your ovaries continue to release eggs for fertilization. Translation: You can still become pregnant.
Premier Health Ob/Gyn physician J. Scott Bembry, MD, says hes seen a handful of patients in his own practice whove become unintentionally pregnant in their late 40s.
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How Do You Know If You’re Still Fertile
You must assume you’re still capable of conceiving until menopause is complete, which has not occurred until menstrual periods have ceased for 12 full months. Menopause is not an on-off switch, says Dr. Stuenkel. But many women dont really understand exactly whats happening.
Ovarian function waxes and wanes in perimenopause, meaning that a woman may release an egg some months but not others. Additionally, body levels of estrogen, progesterone, and other hormones tend to be erratic during this time and egg quality decreases, all contributing to more than a 50 percent decrease in fertility among women 40 and over compared to younger women. But natural conception is still possibleif remotefor women until their mid-fifties.
Early And Premature Menopause And Fertility
Early and premature menopause can affect your ability to have children naturally.
Women experiencing early or premature menopause do not ovulate every month. This makes it difficult to get pregnant.
If you want to have children, you might choose to use IVF and donated eggs from another woman, or using your own eggs if you had some stored. Surrogacy and adoption may also be options for you.
Studies have shown that a small percentage of women experiencing premature menopause do sometimes ovulate and become pregnant.
If you don’t wish to become pregnant you should continue to use contraception.
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Can Mumps Be Prevented
Mumps is a highly preventable disease because of the effectiveness of the MMR vaccine. Children are usually vaccinated against mumps between 12 and 15 months of age and then again between the ages of 4 and 6.
Mumps is considered a rare disease, with only a few hundred cases each year in the United States. Still, outbreaks occur in the United States on a regular basis, especially in places where there is close human contact, such as schools and dormitories. Therefore, it is important that your child be vaccinated to reduce his or her risk of contracting the disease.
So Does That Means Menopause Is Reversal
The latest treatment proposed by Greek scientists suggests that women can stay fertile even after menopause and can conceive with or without monthly menstrual cycles. The investigators also suggests that their treatment would allow women to have a normal pregnancy with their own genetic material without having to go through any hormonal therapy or surgery.
Scientists from Greece developed a new treatment , which is believed to reverse early menopause and atrophic changes in the female reproductive system. According to latest estimates, early menopause affects about 1% of the women population. Some women may experience menopause in their late 30s or early 40s due to a medical or surgical condition .
A team of researchers under Konstantinos Sfakianoudi, a Greek gynecologist and head of Genesis Athens Fertility clinic identified that PRP treatment was able to rejuvenate female reproductive system in early menopausal women . PRP is derived by centrifuging persons own blood sample to obtain a rich concentrate of growth factors and valuable proteins. Once this concentrate is introduced in tissues, the growth factors aids in tissue regeneration. PRP therapies are fairly useful in degenerative bone and joint conditions.
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There Are Some Steps You Can Take To Ease The Pregnancy Journey Before Perimenopause
If you or someone you know is interested in trying to get pregnant later in life but before reaching perimenopause, there are some general guidelines that could help ease the transition.
- Make an appointment before you conceive. Meet with your health care practitioner to discuss your overall health. They might have some suggestions for lifestyle changes that could have a positive effect on improving your chances of a healthy pregnancy.1
- Explore prenatal testing options.There are DNA screenings available to see if your developing baby is at risk. Talk to your doctor about these options.
- Avoid alcohol and tobacco. These substances are definitely off-limits during pregnancy, but given their stress on the body in general, it cant hurt to limit your exposure to them while trying to get pregnant as well.
What Are The Treatments For Poi
It is recommended that women take oestrogen replacement at least until they reach the average age that most women would go through the menopause. This helps protect against the risk of developing osteoporosis , which increases risk of fracture. The two main ways of replacing oestrogen for POI are hormone replacement therapy and the combined contraceptive pill. These both contain the hormones oestrogen and progestogen. They can help relieve many of the symptoms of premature ovarian insufficiency.
There are different types of HRT available. Your doctor will discuss your options with you.
Hormonal treatment is not always suitable for women with a history of breast cancer or another type of cancer stimulated by oestrogen. Ask your doctor about your options if you have a history of cancer.
There are also specialist NHS menopause clinics with an interest in POI across the UK.
You may also be referred to other healthcare professionals who have the right training and experience to help you to manage different aspects of your condition.
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Do People With Turner Syndrome Have Developmental Delays
People with Turner syndrome typically have normal intelligence. But they may have problems with visual motor and visual spatial skills. They can have difficulty seeing how objects relate to each other in space. For example, driving may be difficult.
People with Turner syndrome may also have trouble with:
- Executive functions, including problems with managing and planning, memory, attention, and cognitive flexibility — or changing the way they think about something.
- Nonverbal problem solving, like math.
- Understanding social cues, like facial expressions.